Anti-Caspase-9 Mouse mAb [96E74]
WBIHCIPIF
Anti-Stromal Interaction Molecule 1 Rabbit mAb [57H14]
抗Stromal Interaction Molecule 1兔单克隆抗体 [57H14]
Cat. No.
A52329
Clone No. 57H14
SynonymsStromal Interaction Molecule 1, STIM1, CRACST, ESDY, STIM
详细信息 Product Information
Buffer
50% Glycerol, 0.05% BSA and 0.05% preservative in PBS (pH 7.2-7.4)
Purification
Protein A affinity purification
Concentration
0.2 mg/ml
Storage
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
Shipping
Frozen
Form
Liquid
Calculated MW
77 kDa
Observed MW
77 kDa
Clonality
Monoclonal
Clone No.
57H14
Isotype
IgG, Kappa
抗原与靶点信息 Antigen & Target Information
Gene Name
STIM1
Protein Name
Stromal interaction molecule-1
Background
STIM1 (Stromal Interaction Molecule 1) is ER-resident calcium-sensor protein responsible for CRAC-channel activation and SOCE (store-operated calcium entry). Upon ER-calcium-store depletion, STIM1 oligomerizes and traffics to ER-plasma-membrane junctions, binds and activates plasma-membrane Orai1 channels to trigger massive extracellular Ca2+ influx, controlling T-cell activation, proliferation, migration and secretion. STIM1 deficiency causes immunodeficiency; dysregulated calcium signalling contributes to tumor invasion.
Localization
Endoplasmic Reticulum
Research Area
免疫和传染性疾病
实验信息 Product Usage & Documents
推荐稀释比 Recommended Dilution
WB
1:1000-1:5000
IHC
1:200-1:1000
IP
1:50-1:200
IF
1:200-1:1000
ELISA
1:5000-1:20000
以上为起始稀释比建议，实际需按样本类型与显色体系优化。
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