Anti-Caspase-9 Mouse mAb [96E74]
WBIHCIPIF
Anti-Sumo 1 Rabbit mAb [05G57]
抗Sumo 1兔单克隆抗体 [05G57]
Cat. No.
A52330
Clone No. 05G57
SynonymsSumo 1, SUMO-1, SMT3C, SUMI, small ubiquitin-like modifier 1
详细信息 Product Information
Buffer
50% Glycerol, 0.05% BSA and 0.05% preservative in PBS (pH 7.2-7.4)
Purification
Protein A affinity purification
Concentration
0.2 mg/ml
Storage
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
Shipping
Frozen
Form
Liquid
Calculated MW
12 kDa
Observed MW
80 kDa
Clonality
Monoclonal
Clone No.
05G57
Isotype
IgG, Kappa
抗原与靶点信息 Antigen & Target Information
Gene Name
SUMO1
Protein Name
Small ubiquitin-like modifier-1
Background
SUMO1 (Small ubiquitin-like modifier 1) belongs to SUMO-family of ubiquitin-like modifiers mediating SUMOylation post-translational modification to regulate transcription, nuclear trafficking, DNA-damage repair and protein stability. Through E1/E2/E3 enzymatic cascade, SUMO1 covalently conjugates to lysine residues of target substrates, reshaping protein-protein interaction, subcellular localization and molecular activity. SUMO-1 predominantly mediates mono-SUMOylation rather than poly-SUMO-chains. It participates in PML-body biogenesis and modulates numerous transcription factors including p53 and SP1; de-SUMOylation is catalyzed by SENP proteases. Dysregulated SUMO circuitry is linked to malignancy and neurodegeneration.
Localization
Cytoplasm, Nucleus
Research Area
细胞生物学
实验信息 Product Usage & Documents
推荐稀释比 Recommended Dilution
WB
1:2000-1:10000
IHC
1:2000-1:10000
IF
1:200-1:1000
ELISA
1:5000-1:20000
以上为起始稀释比建议，实际需按样本类型与显色体系优化。
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