Anti-Caspase-9 Mouse mAb [96E74]
WBIHCIPIF
Anti-Survivin Rabbit mAb [72A45]
抗Survivin兔单克隆抗体 [72A45]
Cat. No.
A52331
Clone No. 72A45
SynonymsSurvivin, baculoviral IAP repeat-containing 5, DIABLO antagonist
详细信息 Product Information
Buffer
50% Glycerol, 0.05% BSA and 0.05% preservative in PBS (pH 7.2-7.4)
Purification
Protein A affinity purification
Concentration
0.2 mg/ml
Storage
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
Shipping
Frozen
Form
Liquid
Calculated MW
16 kDa
Observed MW
16 kDa
Clonality
Monoclonal
Clone No.
72A45
Isotype
IgG, Kappa
抗原与靶点信息 Antigen & Target Information
Gene Name
BIRC5
Protein Name
Baculoviral IAP repeat-containing-5
Background
BIRC5 (Survivin) is member of IAP (inhibitor-of-apoptosis-protein) family, functioning both as caspase-apoptosis suppressor and mitotic regulator. In dividing cells Survivin localizes to spindle apparatus and centromeres. It blocks apoptosis via inhibiting effector-caspase activity and supports mitotic progression by assisting spindle assembly and chromosome segregation. It is nearly absent in terminally-differentiated adult tissues but abundantly expressed in embryonic tissues and diverse human tumours, correlating with tumour proliferation, poor prognosis and chemoresistance.
Localization
Cytoplasm
Research Area
癌症
实验信息 Product Usage & Documents
推荐稀释比 Recommended Dilution
WB
1:1000-1:5000
IF
1:200-1:1000
ELISA
1:5000-1:20000
以上为起始稀释比建议，实际需按样本类型与显色体系优化。
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