Anti-Caspase-9 Mouse mAb [96E74]
WBIHCIPIF
Anti-TGF-β1 Rabbit mAb [74G75]
抗TGF-β1兔单克隆抗体 [74G75]
Cat. No.
A52342
Clone No. 74G75
SynonymsTGF-β1, TGFB1 proprotein, Transforming growth factor beta-1
详细信息 Product Information
Buffer
50% Glycerol, 0.05% BSA and 0.05% preservative in PBS (pH 7.2-7.4)
Purification
Protein A affinity purification
Concentration
0.2 mg/ml
Storage
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
Shipping
Frozen
Form
Liquid
Calculated MW
44 kDa
Observed MW
44 kDa, 13 kDa
Clonality
Monoclonal
Clone No.
74G75
Isotype
IgG, Kappa
抗原与靶点信息 Antigen & Target Information
Gene Name
TGFB1
Protein Name
Transforming growth factor-beta-1
Background
TGF-β1 (Transforming growth factor-β1) is secreted cytokine of TGF-β superfamily controlling proliferation, differentiation, apoptosis, EMT, fibrosis and immune-suppression. TGF-β1 is secreted as latent precursor complex; proteolytic cleavage yields active ligand which engages membrane TGF-β receptors to trigger Smad-dependent and Smad-independent downstream cascades. Physiologically it represses epithelial-cell proliferation. It acts as tumour-suppressor in early-stage neoplasia but drives EMT, invasion-metastasis in advanced tumours. It also potently promotes tissue fibrosis and suppresses effector-T-cell-mediated anti-tumour immunity.
Localization
Secreted
Research Area
免疫和传染性疾病
实验信息 Product Usage & Documents
推荐稀释比 Recommended Dilution
WB
1:1000-1:5000
IHC
1:2000-1:5000
IF
1:200-1:1000
ELISA
1:5000-1:20000
以上为起始稀释比建议，实际需按样本类型与显色体系优化。
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