Anti-Caspase-9 Mouse mAb [96E74]
WBIHCIPIF
Anti-KAP1 Rabbit mAb [25H84]
抗KAP1兔单克隆抗体 [25H84]
Cat. No.
A52343
Clone No. 25H84
SynonymsKAP1, AML12, COACH1, SKI-80, AML12 protein
详细信息 Product Information
Buffer
50% Glycerol, 0.05% BSA and 0.05% preservative in PBS (pH 7.2-7.4)
Purification
Protein A affinity purification
Concentration
0.2 mg/ml
Storage
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
Shipping
Frozen
Form
Liquid
Calculated MW
89 kDa
Observed MW
110 kDa
Clonality
Monoclonal
Clone No.
25H84
Isotype
IgG, Kappa
抗原与靶点信息 Antigen & Target Information
Gene Name
TRIM28
Protein Name
KRAB-associated protein-1
Background
TRIM28 (KAP1, KRAB-associated protein 1) is co-repressor for KRAB-zinc-finger proteins, mediating epigenetic silencing, DNA-damage response and retrotransposon repression. Acting as molecular scaffold, KAP1 recruits HDAC, SETDB1 and other epigenetic effector complexes to deposit repressive H3K9me3 marks, driving heterochromatin assembly and silencing endogenous retroviruses (ERV). KAP1 phosphorylation relieves its repressive activity.
Localization
Nucleus
Research Area
表观遗传学
实验信息 Product Usage & Documents
推荐稀释比 Recommended Dilution
WB
1:1000-1:5000
IHC
1:200-1:1000
IF
1:200-1:1000
ELISA
1:5000-1:20000
以上为起始稀释比建议，实际需按样本类型与显色体系优化。
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