Anti-Caspase-9 Mouse mAb [96E74]
WBIHCIPIF
Anti-TLS/FUS Rabbit mAb [45A43]
抗TLS/FUS兔单克隆抗体 [45A43]
Cat. No.
A52344
Clone No. 45A43
SynonymsTLS/FUS, FUS/TLS, TLS, EWSL, EWSR2, FUS/TLS
详细信息 Product Information
Buffer
50% Glycerol, 0.05% BSA and 0.05% preservative in PBS (pH 7.2-7.4)
Purification
Protein A affinity purification
Concentration
0.2 mg/ml
Storage
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
Shipping
Frozen
Form
Liquid
Calculated MW
53 kDa
Observed MW
70 kDa
Clonality
Monoclonal
Clone No.
45A43
Isotype
IgG, Kappa
抗原与靶点信息 Antigen & Target Information
Gene Name
FUS
Protein Name
Fused in sarcoma RNA-binding protein
Background
FUS (FUS/TLS) is FET-family RNA-DNA-binding protein involved in transcriptional control, RNA splicing and RNA trafficking, normally enriched in nucleus. FUS gene mutations or pathological post-translational modifications trigger nuclear-to-cytoplasmic mis-localization and cytoplasmic inclusion-body formation, hallmark lesions of subsets of ALS and FTD. FUS also participates in DNA-damage repair; mutant protein gains toxic properties and perturbs RNA-metabolism networks.
Localization
Cytoplasm, Nucleus
Research Area
神经科学
实验信息 Product Usage & Documents
推荐稀释比 Recommended Dilution
WB
1:500-1:2000
IHC
1:500-1:2000
IF
1:200-1:1000
ELISA
1:5000-1:20000
以上为起始稀释比建议，实际需按样本类型与显色体系优化。
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