50% Glycerol, 0.05% BSA and 0.05% preservative in PBS (pH 7.2-7.4)
Purification
Protein A affinity purification
Concentration
0.2 mg/ml
Storage
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
Shipping
Frozen
Form
Liquid
Calculated MW
44 kDa
Observed MW
44 kDa
Clonality
Monoclonal
Clone No.
32E51
Isotype
IgG, Kappa
抗原与靶点信息
Antigen & Target Information
Gene Name
TSG101
Protein Name
Tumor susceptibility gene-101
Background
TSG101 (Tumor susceptibility gene 101) is core subunit of ESCRT-I complex, mediating multivesicular-body (MVB) biogenesis, endosomal cargo sorting, vesicle budding and exosome biogenesis. As part of ESCRT-I machinery, TSG101 sorts ubiquitinated membrane cargoes into MVBs for lysosomal degradation; it also supports viral budding and cytokinetic abscission. TSG101 perturbation disturbs membrane-protein homeostasis and contributes to oncogenesis.