Anti-Caspase-9 Mouse mAb [96E74]
WBIHCIPIF
Anti-AMPKα1/2 (phospho Thr183/Thr172) Rabbit pAb (A72007)
抗AMPKα1/2 (phospho Thr183/Thr172)兔多克隆抗体
Cat. No.
A72007
SynonymsAMPKα1/2 (phospho Thr183/Thr172), p-AMPK-α1/2(Thr183/172), p-AMPKα(T183/T172), Phospho-AMPKα
详细信息 Product Information
Buffer
50% Glycerol, 0.5% BSA and 0.02% preservative in PBS (pH 7.2-7.4)
Purification
Antigen-affinity-purified
Concentration
1 mg/ml
Storage
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
Shipping
Frozen
Form
Liquid
Calculated MW
62 kDa
Observed MW
63 kDa
Modification
Phospho
Clonality
Polyclonal
Isotype
IgG
抗原与靶点信息 Antigen & Target Information
Gene Name
PRKAA1 / PRKAA2
Protein Name
AMPKα1/2 (phospho Thr183/Thr172)
Domain
human AMPK alpha, around phosphorylation site of Thr172, aa 140-189
Background
Phospho-AMPKα (Thr183/Thr172) corresponds to the conserved activating phosphorylation sites of AMPKα1 and AMPKα2 subunits, which are the hallmark modifications for full AMPK activation. Thr172 on AMPKα2 and Thr183 on AMPKα1 are located in the kinase activation loop, and their phosphorylation is a prerequisite for initiating AMPK catalytic activity and downstream signaling. As a central energy sensor, activated AMPK suppresses anabolic metabolism, promotes catabolic processes, and regulates autophagy, oxidative stress, inflammation and cell growth. Deficient AMPK phosphorylation is a typical pathological feature of metabolic syndrome, aging-related diseases and malignant tumors.
Localization
Cytoplasm, Nucleus
Research Area
代谢
实验信息 Product Usage & Documents
推荐稀释比 Recommended Dilution
WB
1:500-1:2000
IHC
1:100-1:300
IF
1:50-1:200
ELISA
1:40000
以上为起始稀释比建议，实际需按样本类型与显色体系优化。
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