Anti-CD31 Rabbit pAb (A72071)

Antigen-affinity-purified

Platelet-endothelial cell adhesion molecule-1

CD31 (Platelet endothelial cell adhesion molecule-1, PECAM-1) belongs to the immunoglobulin superfamily. It functions in cell-cell adhesion, leukocyte transendothelial migration and vascular homeostasis regulation. CD31 is highly expressed on vascular endothelial cells and platelets, and is also present in some leukocyte subsets. It mediates the formation of tight junctions between endothelial cells via homotypic interactions. Under inflammatory conditions, CD31 mediates leukocyte infiltration and migration across the vascular endothelial barrier to inflammatory sites, participating in angiogenesis and maintenance of vascular barrier integrity. As a classic endothelial cell marker, CD31 is widely used to identify vascular structures and assess tissue vascular density. In tumor research, it is applied to analyze tumor neovascularization, and also used in inflammatory injury models and studies of cardiovascular pathological mechanisms, compatible with multiple immunoassay techniques.

Cell membrane