Anti-Caspase-9 Mouse mAb [96E74]
WBIHCIPIF
Anti-CD86 Rabbit pAb (A72074)
抗CD86兔多克隆抗体
Cat. No.
A72074
SynonymsCD86, B7-2, B70, BB1, CD86 antigen
详细信息 Product Information
Buffer
50% Glycerol, 0.5% BSA and 0.02% preservative in PBS (pH 7.2-7.4)
Purification
Antigen-affinity-purified
Concentration
1 mg/ml
Storage
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
Shipping
Frozen
Form
Liquid
Calculated MW
60-80 kDa
Clonality
Polyclonal
Isotype
IgG
抗原与靶点信息 Antigen & Target Information
Gene Name
CD86
Protein Name
CD86 molecule
Domain
human CD86, aa 115-185
Background
CD86 (Cluster of differentiation 86, B7-2) belongs to B7 co-stimulatory superfamily and delivers co-stimulatory signals for T-cell activation. Predominantly expressed on antigen-presenting cells including dendritic cells, macrophages and B-cells, CD86 maintains low basal expression and is strongly up-regulated upon inflammatory stimulation. It engages T-cell surface CD28 to deliver positive co-stimulation, cooperating with MHC-TCR signaling to drive T-cell proliferation, differentiation and cytokine secretion for adaptive immunity initiation. CD86 also binds CTLA-4 to transmit inhibitory signals for immune homeostasis.
Localization
Cell membrane
Research Area
肿瘤免疫
实验信息 Product Usage & Documents
推荐稀释比 Recommended Dilution
WB
1:500-1:2000
IF
1:100-1:500
ELISA
1:5000-1:20000
以上为起始稀释比建议，实际需按样本类型与显色体系优化。
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