Anti-Caspase-9 Mouse mAb [96E74]
WBIHCIPIF
Anti-Cdc2 Rabbit pAb (A72075)
抗Cdc2兔多克隆抗体
Cat. No.
A72075
SynonymsCdc2, Cell division cycle protein 2 homolog (S. cerevisiae), p34cdc2, MPM2 antigen
详细信息 Product Information
Buffer
50% Glycerol, 0.5% BSA and 0.02% preservative in PBS (pH 7.2-7.4)
Purification
Antigen-affinity-purified
Concentration
1 mg/ml
Storage
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
Shipping
Frozen
Form
Liquid
Calculated MW
34 kDa
Observed MW
34 kDa
Clonality
Polyclonal
Isotype
IgG
抗原与靶点信息 Antigen & Target Information
Gene Name
CDK1
Protein Name
Cyclin-dependent kinase 1
Background
Cdc2 (Cell-division-cycle 2, CDK1) belongs to cyclin-dependent kinase family and serves as master regulator for G2/M transition and mitosis onset. Cdc2 associates with Cyclin B to form maturation-promoting factor (MPF). Its kinase activity is tightly governed by layered phosphorylation. Wee1 introduces inhibitory phosphorylation to keep Cdc2 silent; Cdc25C removes these inhibitory phosphates to activate MPF, triggering nuclear envelope breakdown, spindle assembly and other mitotic events. Cyclin B degradation after mitosis terminates Cdc2 activity. Dysregulated Cdc2 activation causes cell-cycle aberration and genomic instability, and its up-regulation is detected in various cancers.
Localization
Cytoplasm, Nucleus
Research Area
癌症
实验信息 Product Usage & Documents
推荐稀释比 Recommended Dilution
WB
1:500-1:2000
IF
1:50-1:200
ELISA
1:10000
以上为起始稀释比建议，实际需按样本类型与显色体系优化。
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