Anti-GPX4 Rabbit pAb (A72102)

Antigen-affinity-purified

Glutathione peroxidase-4

GPX4 (Glutathione Peroxidase 4) is a key antioxidant enzyme of the glutathione peroxidase family, widely expressed in human nerve, liver, kidney and tumor cells. It coregulates intracellular lipid peroxide clearance, ferroptosis regulation and cellular antioxidant homeostasis. GPX4 specifically degrades intracellular lipid peroxides, inhibits lipid oxidative damage, blocks the ferroptosis process and protects cells from oxidative stress damage. Downregulated expression or functional inactivation of GPX4 is a core inducement of ferroptosis, and its dysfunction leads to lipid toxicity accumulation, induces neurodegenerative diseases and organ ischemia-reperfusion injury, and regulates tumor cell ferroptosis resistance to promote tumor drug resistance and proliferation. As a core target for ferroptosis mechanism and disease targeted research, GPX4 can be specifically regulated by rabbit monoclonal antibodies to intervene in cellular ferroptosis, providing a novel targeted strategy for tumor and degenerative disease treatment.

Cytoplasm