Anti-Caspase-9 Mouse mAb [96E74]
WBIHCIPIF
Anti-STAT3 (phospho Tyr705) Rabbit pAb (A72199)
抗STAT3 (phospho Tyr705)兔多克隆抗体
Cat. No.
A72199
SynonymsSTAT3 (phospho Tyr705), p-STAT3(Tyr705), STAT3, APRF, Signal transducer and activator of transcription 3, Acute-phase response factor
详细信息 Product Information
Buffer
50% Glycerol, 0.5% BSA and 0.02% preservative in PBS (pH 7.2-7.4)
Purification
Antigen-affinity-purified
Concentration
1 mg/ml
Storage
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
Shipping
Frozen
Form
Liquid
Calculated MW
88 kDa
Observed MW
88 kDa
Modification
Phospho
Clonality
Polyclonal
Isotype
IgG
抗原与靶点信息 Antigen & Target Information
Gene Name
STAT3
Protein Name
STAT3 (phospho Tyr705)
Domain
human STAT3, around phosphorylation site of Tyr705, aa 672-721
Background
STAT3 Tyr705 is the major JAK-catalysed tyrosine-phosphorylation site and canonical activation marker of STAT3. Upon stimulation by interleukins, growth factors or cytokines, JAK-mediated Tyr705 phosphorylation triggers STAT3 homodimerization, nuclear translocation and target-gene binding to drive transcription of genes governing proliferation, anti-apoptosis, EMT, inflammation and stem-cell features. Tyr705 phosphorylation is prerequisite for STAT3 nuclear import and transcriptional activity. Constitutive Tyr705 phosphorylation represents a common oncogenic driver across multiple malignancies.
Localization
Nucleus
Research Area
免疫和传染性疾病
实验信息 Product Usage & Documents
推荐稀释比 Recommended Dilution
WB
1:500-1:2000
IHC
1:100-1:300
IP
2-5 μg/mg lysate
IF
1:50-1:200
ELISA
1:20000
以上为起始稀释比建议，实际需按样本类型与显色体系优化。
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