Anti-Caspase-9 Mouse mAb [96E74]
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Anti-STING/TMEM173 Rabbit pAb (A72201)
抗STING/TMEM173兔多克隆抗体
Cat. No.
A72201
SynonymsSTING/TMEM173, STING, MITA, ERIS, MPYS
详细信息 Product Information
Buffer
50% Glycerol, 0.5% BSA and 0.02% preservative in PBS (pH 7.2-7.4)
Purification
Antigen-affinity-purified
Concentration
1 mg/ml
Storage
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
Shipping
Frozen
Form
Liquid
Calculated MW
42 kDa
Observed MW
38 kDa
Clonality
Polyclonal
Isotype
IgG
抗原与靶点信息 Antigen & Target Information
Gene Name
TMEM173
Protein Name
Stimulator of interferon genes
Domain
human Transmembrane protein 173, aa 301-350
Background
TMEM173 (STING, Stimulator of interferon genes) is endoplasmic-reticulum-resident transmembrane adaptor serving as central hub of cGAS-STING innate-immunity pathway for cytosolic-DNA-sensing signal transduction. Cytosolic-DNA-activated cGAS generates second-messenger cGAMP, which binds ER-localized STING and triggers STING oligomerization and Golgi translocation. STING recruits and activates TBK1 kinase to phosphorylate IRF3 and NF-κB, inducing type-I-interferon and pro-inflammatory-cytokine production to initiate antiviral and anti-tumor immune responses. Loss-of-function STING mutations impair cytosolic-DNA immune surveillance, while aberrant STING activation drives auto-inflammatory disorders.
Localization
Endoplasmic Reticulum
Research Area
免疫和传染性疾病
实验信息 Product Usage & Documents
推荐稀释比 Recommended Dilution
WB
1:500-1:2000
IHC
1:100-1:300
IF
1:50-1:200
ELISA
1:20000
以上为起始稀释比建议，实际需按样本类型与显色体系优化。
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