Anti-Caspase-9 Mouse mAb [96E74]
WBIHCIPIF
Anti-CD8α Rabbit pAb (A73005)
抗CD8α兔多克隆抗体
Cat. No.
A73005
SynonymsCD8α, CD8A, CD8, p32, Leu2
详细信息 Product Information
Buffer
0.05% preservative in PBS (pH 7.2-7.4)
Purification
Protein A affinity purification
Concentration
1 mg/ml
Storage
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
Shipping
Frozen
Form
Liquid
Calculated MW
26 kDa
Observed MW
50 kDa
Clonality
Polyclonal
Isotype
IgG
抗原与靶点信息 Antigen & Target Information
Gene Name
CD8A
Protein Name
CD8A molecule
Background
CD8α (Cluster of differentiation 8 alpha) belongs to immunoglobulin superfamily and mediates MHC-I recognition and cytotoxic T-cell activation. CD8α forms heterodimer with CD8β and is predominantly expressed on cytotoxic CD8⁺ T lymphocytes as well as subsets of NK cells. Acting as a co-receptor, it binds MHC-I-peptide complexes on target cells, stabilizes TCR-MHC interaction and recruits Lck tyrosine kinase to amplify TCR signaling. This drives CTL proliferation, granzyme-perforin release and target-cell killing.
Localization
Cell membrane
Research Area
肿瘤免疫
实验信息 Product Usage & Documents
推荐稀释比 Recommended Dilution
WB
1:1000-1:2000
IHC
1:200-1:2000
ELISA
1:5000-1:20000
以上为起始稀释比建议，实际需按样本类型与显色体系优化。
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