Anti-Caspase-9 Mouse mAb [96E74]
WBIHCIPIF
Anti-Aurora B Rabbit pAb (A73029)
抗Aurora B兔多克隆抗体
Cat. No.
A73029
SynonymsAurora B, Aurora-B, AIK2, AIM1, ARK2, AurB, IPL1, STK5, AIM-1, ARK-2, STK-1, STK12, PPP1R48, aurkb-sv1, aurkb-sv2
详细信息 Product Information
Buffer
0.05% preservative in PBS (pH 7.2-7.4)
Purification
Protein A affinity purification
Concentration
1 mg/ml
Storage
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
Shipping
Frozen
Form
Liquid
Calculated MW
39 kDa
Observed MW
54 kDa
Clonality
Polyclonal
Isotype
IgG
抗原与靶点信息 Antigen & Target Information
Gene Name
AURKB
Protein Name
Aurora kinase-B
Background
Aurora B is a core member of the Aurora serine/threonine kinase family encoded by the AURKB gene, serving as a crucial regulator of cell mitosis. Enriched during mitosis and localized at centromeres and spindle midzone, Aurora B governs precise chromosome alignment, spindle assembly checkpoint surveillance, sister chromatid segregation and cytokinesis completion, ensuring the accuracy and stability of cell division. Abnormal overexpression or hyperactivation of Aurora B leads to chromosome segregation errors, genomic instability and uncontrolled cell proliferation, acting as a vital driver of tumorigenesis, invasion and metastasis and a promising target for tumor targeted therapy.
Localization
Nucleus
Research Area
癌症
实验信息 Product Usage & Documents
推荐稀释比 Recommended Dilution
WB
1:1000-1:2000
IHC
1:200-1:2000
ICC/IF
1:100-1:500
ELISA
1:5000-1:20000
以上为起始稀释比建议，实际需按样本类型与显色体系优化。
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