Anti-Caspase-9 Mouse mAb [96E74]
WBIHCIPIF
Anti-STING Rabbit pAb (A73170)
抗STING兔多克隆抗体
Cat. No.
A73170
SynonymsSTING, STING/TMEM173, ERIS, MITA, MPYS, SAVI, NET23, STING, hMITA, hSTING, TMEM173, STING-beta
详细信息 Product Information
Buffer
0.05% preservative in PBS (pH 7.2-7.4)
Purification
Protein A affinity purification
Concentration
1 mg/ml
Storage
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
Shipping
Frozen
Form
Liquid
Calculated MW
42 kDa
Clonality
Polyclonal
Isotype
IgG
抗原与靶点信息 Antigen & Target Information
Gene Name
TMEM173
Protein Name
Stimulator-of-interferon-genes
Background
TMEM173 (STING, Stimulator of interferon genes) is endoplasmic-reticulum-resident transmembrane adaptor serving as central hub of cGAS-STING innate-immunity pathway for cytosolic-DNA-sensing signal transduction. Cytosolic-DNA-activated cGAS generates second-messenger cGAMP, which binds ER-localized STING and triggers STING oligomerization and Golgi translocation. STING recruits and activates TBK1 kinase to phosphorylate IRF3 and NF-κB, inducing type-I-interferon and pro-inflammatory-cytokine production to initiate antiviral and anti-tumor immune responses. Loss-of-function STING mutations impair cytosolic-DNA immune surveillance, while aberrant STING activation drives auto-inflammatory disorders.
Localization
Endoplasmic Reticulum
Research Area
免疫和传染性疾病
实验信息 Product Usage & Documents
推荐稀释比 Recommended Dilution
WB
1:1000-1:2000
ICC/IF
1:100-1:500
ELISA
1:5000-1:20000
以上为起始稀释比建议，实际需按样本类型与显色体系优化。
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