Kirchhammer N, Trefny MP, Auf der Maur P, et al. Combination cancer immunotherapies: Emerging treatment strategies adapted to the tumor microenvironment[J]. Science Translational Medicine, 2022 (Viewpoint).
Focus on the complex interplay between tumors and the immune system, and dissect immunosuppression in the tumor microenvironment. Covering immune checkpoints, cytokine signaling and antigen presentation, these pages explain the regulation of immune-cell activation, exhaustion and infiltration — supporting target discovery and antibody or small-molecule research, and informing immune-cell function assays, TME characterization and pathway-activation studies.
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